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Doctor Lucia Silvotti
~ Researcher ~

Academic profile  

I was born in Parma and educated in Milan.
I was graduated in Biological Sciences in Parma in 1982.
I took my PhD in Molecular Biology and Pathology in 1990. The subject of my thesis was focused on the transforming growth factors secreted by virus-transformed cells.
From 1983 to 1984, as a recipient of a fellowship from the Italian Association for Cancer Research, I worked in the Laboratory of Viral Oncology at the Pasteur Institute of Paris, directed by Prof. L. Montagnier.
From 1993 to 1995 I worked at the Institute of Pathologic Anatomy at the Veterinary Medicine Faculty of Parma.
From 1994 to 1996 I have spent regular terms at the Pasteur Institute of Paris as a Visiting Scientist.
Since 1996 I have been doing research at the section of Physiology of this Department.

(+39) 0521-033890

Research Interests  

My research interests have been focused on viral oncology and immunopathology. More specifically, I investigated the correlation between cellular proliferation, growth factors and aminoacid transport in transformed mammalian cells.
I also studied the role of macrophages on the pathogenesis of AIDS. In collaboration with the University of Pisa and Urbino, I studied the effects of a retroviral drug on macrophages of cats affected by FIV-mediated immunodeficiency.
I also studied the immunotoxicological effects of maternal aflatoxin exposure in weaned piglets.
At present, I am interested in the molecular basis of pheromonal communication in mammals. I am now engaged in a study aimed at understanding the functional role of a family of putative pheromonal receptors that have been discovered in our laboratory.

Recent Publications  

Silvotti L., Montani G., Tirindelli R.
How mammals detect pheromones.
J Endocr. Invest. (in press)


Silvotti L., Belloni L., Umiltà M.A., Mucignat-Caretta C., Tirindelli R.
Differential activation of neurons in the accessory olfactory bulb of pre-pubertal female mice exposed to pheromonal stimuli.
E J Neurosci (submitted).


Biasi E., Silvotti L., Tirindelli R. (2001)
Pheromone detection in rodents.
Neuroreport 12, A81-A84, 2001.


Martini S., Silvotti L., Shirazi A., Ryba N.J.P., Tirindelli R. (2001)
Co-expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ.
Journal of Neuroscience 21, 843-848, 2001.


Kramer L., Silvotti L., Granelli P.,Pollera C., Ferrari C., Bendinelli M., Cabassi E.
Feline Langerhans cells and their possible role in FIV infection.
in Advances in Veterinary Dermatology, Vol.3., pag.117-126,
K.W. Kwochka, C.von Tscharner and T. Willemse eds., 1998.


Silvotti L., Petterino C., Bonomi A., Cabassi E.
Immunotoxicological effects of maternal aflatoxin exposure in weaned piglets.
The Veterinary Record 141, 469-472, 1997.


Silvotti L., Corradi A., Kramer L., Busani L., Tedeschi F., Bendinelli M., Piedimonte G.
Modulation of host cell activation during feline immunodeficiency virus (FIV) infection.
Journal of Comparative Pathology 116, 263-271, 1997.


Silvotti L., Corradi A., Brandi G., Cabassi A., Bendinelli M., Magnani M., Piedimonte G.
FIV induced encephalopathy. early brain lesions in the absence of viral replication in monocyte/macrophages. A pathogenetic model.
Veterinary Immunology and Immunopathology 55, 263-271, 1997.


Silvotti L., Di Lecce R., Bonomi A., Borghetti P., Perillo A., Piedimonte G., Corradi A., Cabassi E.
In vitro responses of macrophages and lymphocytes of pigs fed with aflatoxin B1 and G1.
European Journal of Veterinary Pathology 1, 117-121, 1995.


Magnani M., Rossi L., Fraternale A., Silvotti L., Quintavalla F., Piedimonte G., Matteucci D., Baldinotti F., Bendinelli M.
Feline immunodeficiency virus infection in macrophages. In vitro and in vivo inhibition by ddCTP-loaded erythrocytes.
AIDS Res.Hum.Retrov. 10, 1179-1186, 1994.


Piedimonte G., Montroni M., Silvestri G., Silvotti L., Donatini A., Rossi L., Borghetti A.F., Magnani M.
Phagocytosis reduces HIV-1 production in human monocytes/macrophages infected in vitro.
Archives in Virology 130, 463-469, 1992.


Silvotti L., Piedimonte G., Petronini P.G., Favilla R., Borghetti A.F.
Cell density control of proliferation in A Burkitt lymphoma cell line.
Experimental Hematology 19, 547, 1991.


Silvotti L., Petronini P.G., Borghetti A.F., Wheeler K.P.
The effect of betaine on SV3T3 cells exposed to hypertonicity.
Cell Biology International Reports 14, 257, 1990.


Piedimonte G., Baginski I., Petronini P.G., Silvotti L., Borghetti A.F.
Density-dependent regulation of amino acid transport in a Burkitt lymphoma cell line.
Cancer Letters 47, 121-125, 1989.


Petronini P.G., Tramacere M., Mazzini A., Piedimonte G., Silvotti L., Borghetti A.F.
Hyperosmolarity-induced stress proteins in chick embryo fibroblasts.
Experimental Cell Research, 172, 450-462, 1987.


Silvotti L., Petronini P.G., Borghetti A.F.
Stress proteins induction in quiescent, growing and transformed 3T3 cells.
European Journal of Cell Biology 42 (16), 23, 1986.


Piedimonte G., Silvotti L., Chamaret S., Borghetti A.F., Montagnier L.
Association of tyrosine protein kinase activity with mitochondria in human fibroblasts.
Journal of Cellular Biochemistry, 32, 113-123, 1986.


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