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Professor Roberto Tirindelli
~ Associate Professor of Physiology ~

Academic profile  

I was born in Cremona and took the degree in Veterinary Medicine and the abilitation at the University of Parma.

After a year as a postdoc at the University of Pisa, I moved to the Department of Biochemistry and Molecular Biology of the Leeds University (UK) where I spent three years as a Research Fellow.

In 1990, I was appointed at the Medical School of the Parma University as a Assistant Professor in Physiology.

From 1992 to 2000 I have spent regular terms at the National Institutes of Health (Bethesda) as a Visiting Scientist.

In 2001, I became Associate Professor in Physiology.

(+39) 0521-903890

Research Interests  

My research interest have always been focused on the mechanisms that regulate the sensory signal transduction in Vision and Olfaction.

My actual aim is to understand the molecular basis of the pheromonal communication in mammals.

Recent Publications  

Ghiaroni V., Fieni F., Tirindelli R., Pietra P. and Bigiani A.
Voltage-dependent Na and K currents in supporting cells of the mouse vomeronasal organ.
J. Neurophysiol. (in press).


Biasi E., Silvotti L., Tirindelli R.
Pheromone detection in rodents.
Neuroreport. 12(14): A81-4, 2001.

Martini S., Silvotti L., Shirazi A., Ryba N.J.P. and Tirindelli R.
Co-expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ.
J. Neurosci. 21: 843-848, 2001.

Giacobini P., Benedetto A., Tirindelli R. and Fasolo A.
Proliferation and migration of receptor neurons in the vomeronasal organ of the adult mouse.
Dev. Brain Res. 123: 33-40, 2000.

Cavaggioni A., Mucignat C., and Tirindelli R.
Pheromone signalling in the mouse: role of urinary proteins and vomeronasal organ.
Archives Italiennes de Biologie, 137: 193-200, 1999.

Tirindelli R., Mucignat C., Caretta A. and Ryba N.J.P.
Molecular aspects of pheromonal communication via the vomeronasal organ of mammals.
Trends Neurosci. 21: 451-501, 1998.

Ryba N.J.P. and Tirindelli R.
Mammalian pheromone reception: of mice and men?
Modern Drug Discov. Sept/Oct , 55-62, 1998.

Ryba N.J.P. and Tirindelli R.
A new multigene family of putative pheromone receptors in mammals.
Neuron, 19: 371-379, 1997.

Ferrari E., Lodi T., Sorbi R.T., Tirindelli R., Cavaggioni A., Spisni A.
Expression of a Lipocalin in Pichia Pastoris: Secretion, purification, and binding activity of a recombinant Major Urinary Protein.
FEBS Lett., 401: 73-77, 1997.

Cavaggioni A., Mucignat C., Sartor G. and Tirindelli R.
The vomeronasal organ.
Neurobiology, Ed. Torre and Conti. Plenum Press, New York, 165-173, 1996.

Wu Y., Tirindelli R., Ryba N.J.P.
Evidence for differences in the chemosensory signal transduction pathways of olfactory and vomeronasal neurones.
Biochem. Biophys. Res. Commun. 220: 900-904, 1996.

Tirindelli R., Ryba N.J.P.
The G-Protein gamma-subunit, G gamma 8, is expressed in the developing axons of olfactory and vomeronasal neurones.
Eur. J. Neurosci. 8: 2388-2398, 1996.

Ryba N.J.P., Tirindelli R.
The novel GTP-binding protein gamma-subunit is expressed during neurogenesis in the vomeronasal and olfactory epithelium.
J. Biol. Chem. 270: 6757-6767, 1995.

Ryba N.J.P., Paini M., Tirindelli R.
Construction of an olfactory cDNA differential library.
Mol. Biol. (Life Sci. Adv.) 13: 101-105, 1994.

Bocksey Z.S., Findlay J.B.C., North A.C.T., Philipps S.E.V., Somers W.S., Wright C.E., Lionetti C., Tirindelli R., Cavaggioni A.
Crystallisation and preliminary x-ray data for the mouse Major Urinary Protein and rat alfa-2u Globulin.
J. Mol. Biol. 218: 669-701, 1991.

Ryba N.J.P., Hall M., Findlay J.B.C. and Tirindelli R.
A method for efficient and rapid cloning of cDNA into lambda gt10 that facilitates directional subcloning into plasmid vectors.
Nucleic Acids Res. 19: 1953, 1991.

Caretta A., Sorbi R.T., Stein P.J., Tirindelli R.
Diltiazem at high concentration increases the ionic permeability of biological membranes.
J. Membr. Biol. 122: 203-213, 1991.

Caretta A., Cevolani D., Luppino G., Matelli M., Tirindelli R.
Characterisation and regional distribution of a class of synapses with highly concentrated cAMP binding sites in the rat brain.
Eur. J. Neurosci. 3: 669-687, 1991.

Bignetti E., Cavaggioni A., Tirindelli R.
The chemistry of chemoreception in vertebrate sensory systems.
Sensory Transduction Ed. Borsellino et al. 194: 67-80, 1990.

Cavaggioni A., Findlay J.B.C., Tirindelli R.
Ligand binding characteristics of homologous rat and mouse urinary protein and pyrazine binding protein of calf.
Comp. Biochem. Physiol. 96A: 513-520, 1990.

Caretta A., Stein P.J., Tirindelli R.
Rhodopsin-detergent micelles aggregate upon activation of cGMP phosphodiesterase.
Biochemistry 20: 2652-2657, 1990.

Tirindelli R., Keen J.K., Cavaggioni A., Eliopulos E.E., Findlay J.B.C.
Complete aminoacid sequence of the pyrazine binding protein from cow nasal mucosa.
Eur. J. Biochem. 185: 569-572, 1989.

Pelosi P., Tirindelli R.
Structure-activity studies of the pyrazine binding protein. Receptor and transduction mechanisms in taste and olfaction.
M. Dekker, New York, 1: 207-226, 1989.

Bignetti E., Cattaneo P., Cavaggioni A., Damiani G., Tirindelli R.
The pyrazine binding protein and olfaction.
Comp. Biochem. Physiol. 90B: 1-5, 1988.

Avanzini F., Bignetti E., Bordi C., Carfagna G., Cavaggioni G., Ferrrari G., Sorbi R.T., Tirindelli R.
Immunocytochemical localisation of the pyrazine binding protein in bovine nasal mucosa.
Cell Tissue Res. 247: 461-464, 1987.

Bignetti E., Sorbi R.T., Tirindelli R.
Effect of fluoride on the phosphodiesterase of bovine photoreceptors.
Vision Res. 26: 383-389, 1986.

Bignetti E., Tirindelli R., Rossi G.L., Bolognesi M., Coda A. Gatti G.
Crystallisation of an odorant binding protein from cow nasal mucosa.
J. Mol. Biol. 186: 211-212, 1985.

Bignetti E., Cavaggioni A., Pelosi P., Persaud K.C., Sorbi R.T., Tirindelli R.
Purification and characterization of an odorant binding protein from cow nasal tissue.
Eur. J. Biochem. 149: 227-233, 1985.

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